Fire crews were called to the scene of an office fire at the Jefferson Motel.
The call came in to 911 dispatchers just after midnight Friday.
Smoke was seen billowing from the motel office located along Route 60 in Jefferson.
The fire chief confirmed that it was a grease fire.
He estimated 24-30 people are displaced, and they are calling in the Red Cross.
Route 60 was closed for a time between Venture Lanes and the South Charleston city line.