A Toyota Echo was traveling the wrong direction on I-64 and collided with a Ford Mustang.
The accident resulted in non-life threatening injuries.
Both lanes are now open.
Both Eastbound lanes of I-64 near the Fifth street exit were closed just before 6 p.m. due to an accident.
911 dispatchers say they had calls of a car going the wrong way on the road.
First responders are still on the scene.
Drivers are asked to avoid the area and use alternate routes.
We have a crew on the scene and will bring you more information as it becomes available.